Biography
Chris E. Freise, M.D. received his medical degree from the University of Minnesota where he also did his internship and residency in General Surgery. He later completed a transplantation fellowship at UCSF.
He is a member of numerous professional organizations including The Transplantation Society, the International Pancreas and Islet Transplant Association, the Transplant Infectious Disease Society, the American Hepato-Pancreato-Billiary Association and the Society of University Surgeons. In addition, he recently served as the Medical Director for California Transplant Donor Network. He is also the Associate Counselor for UNOS Region 5, and a member of the UNOS Membership and Professional Standards Committee.
Dr. Freise has authored more than eighty (80) in peer-reviewed publications and five (5) book chapters. He is an accomplished researcher and clinical educator. Dr. Freise is also a frequent invited lecturer to national and international and conferences in the field.
Education
| Institution | Degree | Dept or School | End Date | 
|---|---|---|---|
| University of California | Diversity, Equity, and Inclusion Champion Training | 2019 | |
| University of California, San Francisco | Transplant Fellowship | School of Medicine | 1995 | 
| University of California, San Francisco | Post-Doc Fellow/Scholar | School of Medicine | 1991 | 
| University of Minnesota | M.D. | School of Medicine | 1986 | 
Board Certifications
- American Board of Surgery, 1995
Clinical Expertise
Bile Duct Injuries
Bile Duct Strictures
Cholangiocarcinoma (Bile Duct Cancer)
Choledochal Cyst Disease
Dialysis Access
Expanded Criteria Donor Kidney Transplantation
Fulminant Hepatic Failure
Hepatitis B
Hepatitis C
Hepatocellular Carcinoma (Liver Cancer)
Intestinal Transplantation and Rehabilitation
Kidney and LIver Transplantation in HIV Patients
Kidney Auto-transplantation
Kidney Transplantation
Laparoscopic Donor Nephrectomy
Laparoscopic Kidney and Liver Surgery
Liver Transplantation
Living Donor Kidney Transplantation
Living Donor Liver Transplantation
Pancreas Transplantation
Pediatric Kidney Transplantation
Pediatric Liver Transplantation
Polycystic Kidney Disease
Polycystic Liver Disease
Portal Hypertension
Surgical Shunts
In the News
Grants and Funding
- Living Donor Liver Transplant :Short & Long-Term Impact on Donors and Recipients | NIH | 2002-09-01 - 2015-08-31 | Role: Principal Investigator
Research Narrative
Dr. Friese's basic science research focuses on the delivery of immunosuppressive agents to organ allografts, ischemia reperfusion injury, and methods to improve organ function in deceased donors. His clinical research includes a multicenter trial investigating donor and recipient outcomes following living donor liver transplantation.
Research Interests
Delivery of Immunosuppressive Agents to Organ Allografts
Ischemia Reperfusion Injury
Improvement Organ Function in Deceased Donors
Publications
- Ureteral avulsion after ureteroscopy treated with renal auto-transplantation.| | PubMed PubMed
- Abdominal lymphocele following multi-level anterior lumbar interbody fusion (ALIF) managed with a laparoscopic peritoneal window: case report and review of the literature.| | PubMed PubMed
- Peritoneal Dialysis Catheter Complications after Insertion by Surgeons, Radiologists, or Nephrologists.| | PubMed PubMed
- DCD liver transplant in patients with a MELD over 35.| | PubMed PubMed
- Advantages and Limitations of Clinical Scores for Donation After Circulatory Death Liver Transplantation.| | PubMed PubMed
- Motivations and outcomes of compatible living donor-recipient pairs in paired exchange.| | PubMed PubMed
- Retransplantation After Living Donor Liver Transplantation: Data from the Adult to Adult Living Donor Liver Transplantation Study.| | PubMed PubMed
- Biliary obstruction following ureteral revision of a transplanted kidney.| | PubMed PubMed
- Setting rules for the sandbox: A response to "Successfully sharing the sandbox: A perspective on combined DCD liver and heart donor procurement".| | PubMed PubMed
- Treatment of immunocompromised COVID-19 patients with convalescent plasma.| | PubMed PubMed
- Opioid use prior to liver transplant is associated with increased risk of death after transplant.| | PubMed PubMed
- Molecular Insights in Transmission of Cancer From an Organ Donor to Four Transplant Recipients.| | PubMed PubMed
- Contemporary Management of Hepatic Cyst Disease: Techniques and Outcomes at a Tertiary Hepatobiliary Center.| | PubMed PubMed
- Impact of Sarcopenia on Simultaneous Pancreas and Kidney Transplantation Outcomes: A Retrospective Observational Cohort Study.| | PubMed PubMed
- Inferior Long-Term Graft Survival of Suboptimal Kidneys After Living Donor Kidney Transplantation.| | PubMed PubMed
- Rapid Modification of Workflows and Fellow Staffing at a Single Transplant Center to Address the COVID-19 Crisis.| | PubMed PubMed
- Non-contact monitoring of agitation and use of a sheltering device in patients with dementia in emergency departments: a feasibility study.| | PubMed PubMed
- Living Donor Liver Transplant for Alcoholic Liver Disease: Data from the Adult-to-adult Living Donor Liver Transplantation Study.| | PubMed PubMed
- Bi-organ paired exchange-Sentinel case of a liver-kidney swap.| | PubMed PubMed
- Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study.| | PubMed PubMed
- Splenic Vein Thrombosis Following Pancreas Transplantation: Identification of Factors That Support Conservative Management.| | PubMed PubMed
- Collagen XIV and a related recombinant fragment protect human vascular smooth muscle cells from calcium-/phosphate-induced osteochondrocytic transdifferentiation.| | PubMed PubMed
- Pancreas-After-Islet Transplantation in Nonuremic Type 1 Diabetes: A Strategy for Restoring Durable Insulin Independence.| | PubMed PubMed
- Vascular complication rates in living donor liver transplantation: How low can we go?| | PubMed PubMed
- A Single Perioperative Injection of Dexamethasone Decreases Nausea, Vomiting, and Pain after Laparoscopic Donor Nephrectomy.| | PubMed PubMed
- De novo thyroid cancer following solid organ transplantation-A 25-year experience at a high-volume institution with a review of the literature.| | PubMed PubMed
- Social and Financial Outcomes of Living Liver Donation: A Prospective Investigation Within the Adult-to-Adult Living Donor Liver Transplantation Cohort Study 2 (A2ALL-2).| | PubMed PubMed
- Early Postoperative Pain and its Predictors in the Adult to Adult Living Donor Liver Transplantation Cohort Study.| | PubMed PubMed
- Impact of Graft Selection on Donor and Recipient Outcomes After Living Donor Liver Transplantation.| | PubMed PubMed
- Psychosocial Outcomes 3 to 10 Years After Donation in the Adult to Adult Living Donor Liver Transplantation Cohort Study.| | PubMed PubMed
- Complications and Their Resolution in Recipients of Deceased and Living Donor Liver Transplants: Findings From the A2ALL Cohort Study.| | PubMed PubMed
- Defining long-term outcomes with living donor liver transplantation in North America.| | PubMed PubMed
- Laparoscopic Nephrectomy with Autotransplantation: Safety, Efficacy and Long-Term Durability.| | PubMed PubMed
- Liver regeneration after living donor transplantation: adult-to-adult living donor liver transplantation cohort study.| | PubMed PubMed
- Long-term quality of life after liver donation in the adult to adult living donor liver transplantation cohort study (A2ALL).| | PubMed PubMed
- Restricting liver transplant recipients to younger donors does not increase the wait-list time or the dropout rate: the hepatitis C experience.| | PubMed PubMed
- Emesis following laparoscopic left donor nephrectomy.| | PubMed PubMed
- Wideband MRE and static mechanical indentation of human liver specimen: sensitivity of viscoelastic constants to the alteration of tissue structure in hepatic fibrosis.| | PubMed PubMed
- Ex vivo split-liver transplantation: the true right/left split.| | PubMed PubMed
- Outcomes of living and deceased donor liver transplant recipients with hepatocellular carcinoma: results of the A2ALL cohort.| | PubMed PubMed
- Risk factors for liver transplant waitlist dropout in patients with hepatocellular carcinoma.| | PubMed PubMed
- Complications of living donor hepatic lobectomy--a comprehensive report.| | PubMed PubMed
- Use of living donor liver transplantation varies with the availability of deceased donor liver transplantation.| | PubMed PubMed
- Outcomes with split liver transplantation in 106 recipients: the University of California, San Francisco, experience from 1993 to 2010.| | PubMed PubMed
- Liver transplantation for giant hepatic angiomyolipoma.| | PubMed PubMed
- Experience with laparoscopic donor nephrectomy among more than 1000 cases: low complication rates, despite more challenging cases.| | PubMed PubMed
- Ten-year retrospective analysis of incisional herniorrhaphy following renal transplantation.| | PubMed PubMed
- Fibrin plug.| | PubMed PubMed
- Outcomes of surgical repair of bile leaks and strictures after adult-to-adult living donor liver transplant.| | PubMed PubMed
- Comparison of biliary complications in adult living-donor liver transplants performed at two busy transplant centers.| | PubMed PubMed
- Inguinal herniation of a transplant ureter.| | PubMed PubMed
- Emergent orthotopic liver transplantation for hemorrhage from a giant cavernous hepatic hemangioma: case report and review.| | PubMed PubMed
- Left lobe adult-to-adult living donor liver transplantation: small grafts and hemiportocaval shunts in the prevention of small-for-size syndrome.| | PubMed PubMed
- Open incisional hernia repair at an academic tertiary care medical center.| | PubMed PubMed
- Prostate cancer screening and treatment in the transplant population: current status and recommendations.| | PubMed PubMed
- Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinoma.| | PubMed PubMed
- Recipient morbidity after living and deceased donor liver transplantation: findings from the A2ALL Retrospective Cohort Study.| | PubMed PubMed
- Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: an intention-to-treat analysis.| | PubMed PubMed
- Outcomes of living donor liver transplantation for acute liver failure: the adult-to-adult living donor liver transplantation cohort study.| | PubMed PubMed
- Donor morbidity after living donation for liver transplantation.| | PubMed PubMed
- Organ donation and utilization in the United States, 1997-2006.| | PubMed PubMed
- HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes.| | PubMed PubMed
- Long-term outcomes and late complications of laparoscopic nephrectomy with renal autotransplantation.| | PubMed PubMed
- Catheter-directed therapy for DVT after pancreas transplantation.| | PubMed PubMed
- Laparoscopic nephrectomy, ex vivo partial nephrectomy followed by allograft renal transplantation.| | PubMed PubMed
- Improvement in survival associated with adult-to-adult living donor liver transplantation.| | PubMed PubMed
- Hepatocellular carcinoma recurrence and death following living and deceased donor liver transplantation.| | PubMed PubMed
- Glutamine donor pretreatment in rat kidney transplants with severe preservation reperfusion injury.| | PubMed PubMed
- Predicting biliary complications in right lobe liver transplant recipients according to distance between donor's bile duct and corresponding hepatic artery.| | PubMed PubMed
- Effect of mycophenolate mofetil on rat kidney grafts with prolonged cold preservation.| | PubMed PubMed
- A prospective study on downstaging of hepatocellular carcinoma prior to liver transplantation.| | PubMed PubMed
- End stage polycystic kidney disease: indications and timing of native nephrectomy relative to kidney transplantation.| | PubMed PubMed
- More than 500 consecutive laparoscopic donor nephrectomies without conversion or repeated surgery.| | PubMed PubMed
- Outcomes of 385 adult-to-adult living donor liver transplant recipients: a report from the A2ALL Consortium.| | PubMed PubMed
- Laparoscopic procurement of kidneys with multiple renal arteries is associated with increased ureteral complications in the recipient.| | PubMed PubMed
- H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants.| | PubMed PubMed
- BKV in simultaneous pancreas-kidney transplant recipients: a leading cause of renal graft loss in first 2 years post-transplant.| | PubMed PubMed
- Laparoscopic right donor nephrectomy: a large single-center experience.| | PubMed PubMed
- Increased rejection in living unrelated versus living related kidney transplants does not affect short-term function and survival.| | PubMed PubMed
- Laparoscopic nephrectomy, ex vivo excision and autotransplantation for complex renal tumors.| | PubMed PubMed
- Early graft function after living donor kidney transplantation predicts rejection but not outcomes.| | PubMed PubMed
- Laparoscopic-assisted upper pole ureterocalicostomy using renal inversion and autotransplantation.| | PubMed PubMed
- Experience with steroid-free maintenance immunosuppression in simultaneous pancreas-kidney transplantation.| | PubMed PubMed
- Polyomavirus-associated nephropathy in simultaneous kidney-pancreas transplant recipients: a single-center experience.| | PubMed PubMed
- Technique, indications and outcomes of pure laparoscopic right donor nephrectomy.| | PubMed PubMed
- Pure laparoscopic right donor nephrectomy: step-by-step approach.| | PubMed PubMed
- Influence of donor pretreatment with N-acetylcysteine on ischemia/reperfusion injury in rat kidney grafts.| | PubMed PubMed
- Laparoscopic donor nephrectomy for pediatric recipients: outcomes analysis.| | PubMed PubMed
- Sirolimus delays recovery of rat kidney transplants after ischemia-reperfusion injury.| | PubMed PubMed
- Excellent short-term results with steroid-free maintenance immunosuppression in low-risk simultaneous pancreas-kidney transplantation.| | PubMed PubMed
- Laparoscopic radical nephrectomy for suspected renal cell carcinoma in dialysis-dependent patients.| | PubMed PubMed
- Kidney and liver transplantation in human immunodeficiency virus-infected patients: a pilot safety and efficacy study.| | PubMed PubMed
- Management of lymphoceles after renal transplantation: laparoscopic versus open drainage.| | PubMed PubMed
- Sclerosing peritonitis.| | PubMed PubMed
- Expanded experience with laparoscopic nephrectomy and autotransplantation for severe ureteral injury.| | PubMed PubMed
- Techniques to optimize vascular control during laparoscopic donor nephrectomy.| | PubMed PubMed
- Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice.| | PubMed PubMed
- Successful long-term outcomes using pediatric en bloc kidneys for transplantation.| | PubMed PubMed
- Laparoscopic nephrectomy and autotransplantation for severe iatrogenic ureteral injuries.| | PubMed PubMed
- A calcineurin inhibitor-sparing regimen with sirolimus, mycophenolate mofetil, and anti-CD25 mAb provides effective immunosuppression in kidney transplant recipients with delayed or impaired graft function.| | PubMed PubMed
- Experience with the use of sirolimus in liver transplantation--use in patients for whom calcineurin inhibitors are contraindicated.| | PubMed PubMed
- Prolonged cold ischemia time obviates the benefits of 0 HLA mismatches in renal transplantation.| | PubMed PubMed
- The effect of age and prolonged cold ischemia times on the national allocation of cadaveric renal allografts.| | PubMed PubMed
- Flow cytometry crossmatching as a predictor of acute rejection in sensitized recipients of cadaveric renal transplants.| | PubMed PubMed
- Liver transplantation for autoimmune hepatitis: rejection and recurrence.| | PubMed PubMed
- Effect of systemic cyclosporine on tumor recurrence after liver transplantation in a model of hepatocellular carcinoma.| | PubMed PubMed
- Simultaneous pancreas-kidney transplantation: an overview of indications, complications, and outcomes.| | PubMed PubMed
- Hepatic artery pseudoaneurysm with hemobilia following angioplasty after liver transplantation.| | PubMed PubMed
- Risks associated with conversion of stable patients after liver transplantation to the microemulsion formulation of cyclosporine.| | PubMed PubMed
- Increased morbidity and mortality of simultaneous pancreas-renal transplantation in patients over 49 years of age.| | PubMed PubMed
- Liver transplantation improves survival of rats bearing hepatoma-3924A.| | PubMed PubMed
- Hepatotoxins and liver transplantation decrease pulmonary metastases in rats with hepatoma.| | PubMed PubMed
- Low postoperative wound infection rates are possible following simultaneous pancreas-kidney transplantation.| | PubMed PubMed
- Increased efficacy of CSA following rearterialization in the rat OLTX model.| | PubMed PubMed
- The increased efficacy and decreased nephrotoxicity of a cyclosporine liposome.| | PubMed PubMed
- Major histocompatibility complex class I deficiency prolongs islet allograft survival.| | PubMed PubMed
- Nonoperative management of biliary leaks after orthotopic liver transplantation.| | PubMed PubMed
- Maintenance immunosuppression with prednisone and RS-61443 alone following liver transplantation.| | PubMed PubMed
- Isolation of functional MHC class I-deficient islet cells.| | PubMed PubMed
- Orthotopic liver transplantation for end-stage alcoholic liver disease.| | PubMed PubMed
- Acute liver rejection: evaluation with cell-directed MR contrast agents in a rat transplantation model.| | PubMed PubMed
- A modified vascular "sleeve" anastomosis for rearterialization in orthotopic liver transplantation in rats.| | PubMed PubMed
- Similar clinical presentation of neurotoxicity following FK 506 and cyclosporine in a liver transplant recipient.| | PubMed PubMed
- Wound healing after anorectal surgery in human immunodeficiency virus-infected patients.| | PubMed PubMed
- Demonstration of local immunosuppression with methylprednisolone in the sponge matrix allograft model.| | PubMed PubMed
- Characterization of a cyclosporine-containing liposome.| | PubMed PubMed
- Comparison of three regimens for cytomegalovirus prophylaxis in 147 liver transplant recipients.| | PubMed PubMed
- MHC expression on human hepatocytes before and after isolation.| | PubMed PubMed
 
     
